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KMID : 0604520150410030201
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 3 p.201 ~ p.208
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Development of Lecithin Organogel to Improve Solubility of Genistein
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Lee Soo-Jin
Kim Jung-A
Kang Nae-Gyu
Park Sun-Gyoo
Lee Cheon-Koo
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Abstract
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Organogels are semi-solid systems that consist of an apolar solvent as the liquid phase within a three-dimen-sional networked structure. In this study, we developed a stable and skin penetration-enhanced Lecithin Organogel (LO) containing genistein, which is one of the poorly soluble active ingredients in both polar and apolar phase. After screen-ing of various components (type of gelators, organic and aqueous phase), hydrogenated lecithin (HL), sunflower oil (SO), dipropylene glycol (DPG), and polyethylene glycol (PEG) were mainly used in this formulation. Phase ternary diagram was employed for optimization of the composition in the LO. The formulated LO were evaluated for its organoleptic characteristics, stability, pH, rheology, phase transition temperatures, microscopic analysis and skin penetration. The opti-mized stable LO system can be utilized as an effective and stable cosmetic formulation that can carry poorly soluble active ingredients at high concentration for topical dermal delivery.
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KEYWORD
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cosmetic, organogel, lecithin, skin penetration, genistein
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